The research
The following provides a detailed explanation of the scientific background of the study, the applied research methods, and the research objectives.
Scientific background of the study
Physiological Adaptations During Pregnancy
Pregnancy is characterized by a multitude of finely-tuned physiological adaptations to meet the demands of the developing fetus and prepare the maternal organism for delivery and lactation. These changes impact maternal metabolism, cardiovascular, immune, microbiome, and endocrine systems.
Impact of Adverse Factors
Unfavorable or adverse maternal factors, such as endocrine, genetic, metabolic, and lifestyle factors, may compromise these adaptations, leading to pregnancy complications like gestational diabetes, hypertensive pregnancy disorders, fetal growth restriction, fetal overgrowth, or preterm birth. Not only do these pathologies pose immediate health risks to both mother and child, but they can also adversely affect the long-term cardiovascular, endocrine, and metabolic health of both.
The Role of Positive Influences
Concurrently, there are also positive influences during pregnancy that can have beneficial effects on the health of the mother and fetus. These may include factors such as optimal nutrition, physical activity, emotional well-being, and a supportive environment. However, the extent and mechanisms of these positive influences are not yet fully understood and are a significant area of ongoing research. Understanding these beneficial factors is just as crucial as identifying the adverse ones, as they can contribute to better pregnancy outcomes and long-term health.
Objective of the Prospective Study
The concept of deep phenotyping during pregnancy has emerged as a crucial approach to address the inadequate understanding of the pathobiology of pregnancy-related diseases and health trajectories. This method involves a combination of advanced body composition analysis, biochemical phenotyping, glycobiology, and comprehensive biosample collection (blood, urine, cord blood, milk, hair, saliva). A key aspect of this multidisciplinary approach is not only to develop precise intervention strategies for pregnancy-related illnesses but also to identify and leverage positive stimuli. Recognizing these beneficial influences is vital for enhancing pregnancy outcomes and promoting the long-term health of mother and child. By understanding both the adverse and positive factors at play, we can create more holistic and effective approaches to maternal and fetal health.
Location
Department of Gynaecology and Obstetrics, Auenbruggerplatz 14, 8036 Graz
Contact
- Write us your request
- pregwin@medunigraz.at
- www.pregwin.at
